WE KEEP IT SIMPLE
BUT SIGNIFICANT.
Custom Molecular Biology Services
From targeted mutations to custom plasmid construction
We provides reliable, high-quality molecular biology services for academic laboratories, research institutions, and biotechnology companies.
From a single targeted mutation to complex DNA assembly, our scientific team reviews each project and develops an appropriate cloning strategy to deliver a sequence-verified construct ready for your research.
Prices are in Canadian dollars and do not include taxes.
Targeted Mutagenesis
Precise. Verified. Ready to use.
Introduce substitutions, small insertions, or deletions into your plasmid without having to perform the cloning and screening yourself.
Template plasmid size (Kb)
Up to 6
6-8
8-10
10-12
*Obtain discount of 10 % for more than 10 plasmids to modify
+ $80 per additional mutation in the same template plasmid
Price ($)*
$160 / per mutation
$180 / per mutation
$200 / per mutation
$250 / per mutation
Project specifications
Modification
Maximum plasmid size
Customer-supplied vector
Plasmid Storage
Sequence verification
DNA delivered
Turnaround time
Any combination of substitutions, small insertions or deletions within a 10 bp region
12 kb
No additional vector preparation fee**
Free of charge for long-term storage and future projects
Full-length plasmid sequence/map provided
2–5 µg purified plasmid DNA
10–20 business days
**Customer-supplied plasmids must meet Genome ProLab submission requirements. See here.
Need something more complex?
Custom Plasmid Construction
From a simple subcloning project to a multi-fragment DNA assembly, Genome ProLab can design and execute the cloning strategy for your construct.
Because cloning difficulty can vary considerably depending on plasmid size, insert size, sequence complexity, number of fragments and the required cloning strategy, each custom project is scientifically evaluated before the final quotation is issued.
Our custom services
Gibson Assembly
Assembly of two or more DNA fragments into your plasmid of interest.
Subcloning
Transfer an insert, gene, regulatory sequence, tag, or other DNA element into a new vector.
PCR Cloning
PCR amplification and cloning of your sequence into the desired construct.
Large Insertions & Deletions
Introduce larger sequence modifications that fall outside our standard targeted mutagenesis service.
Gateway Cloning
Transfer sequences between Gateway-compatible entry and destination vectors.
Golden Gate Cloning
Seamless assembly of multiple DNA fragments into your desired vector using Type IIS restriction enzymes.
gRNA Cloning
Cloning of guide RNA sequences into compatible CRISPR/Cas vectors.
Gene Synthesis & Cloning
Have a DNA sequence synthesized and incorporated into the vector required for your project.
Custom Plasmid Construction
More complex plasmid modifications, including combinations of cloning strategies.
Custom project specifications
Project type
Typical price range
DNA delivered
Sequence verification
Turnaround time
Complex projects
Custom-designed according to your construct
Starting at $160 / construct or modification
2–5 µg purified plasmid DNA
Final full-length plasmid sequence/map provided
Typically 10–20 business days
Individual quotation